The 2019 Caribbean Series is set to commence on Monday in Panama. All 13 games will be played at Rod Carew Stadium in Panama City. Lenadores de Las Tunas (CUB), Charros de Jalisco (MEX), Toros de Herrera (PAN), Cangrejeros de Santurce (PUR), Estrellas Orientales (DOM) and Cardenales de Lara (VEN) will be the six participants. The teams are split into two groups with the round robin winners advancing directly to the final. All games will be broadcasted by ESPN Deportes and the streaming website of the Liga Mexicana del Pacifico.
Schedule:
Group A Schedule:
| Date | Time (ET) | Home | Away |
| February 4 | 8:00 PM | Mexico | Venezuela |
| February 5 | 3:00 PM | Cuba | Mexico |
| February 6 | 3:00 PM | Cuba | Venezuela |
| February 7 | 3:00 PM | Mexico | Cuba |
| February 8 | 8:00 PM | Venezuela | Mexico |
| February 9 | 1:00 PM | Venezuela | Cuba |
Group B Schedule:
| Date | Time (ET) | Home | Away |
| February 4 | 3:00 PM | Dominican Republic | Puerto Rico |
| February 5 | 8:00 PM | Dominican Republic | Panama |
| February 6 | 8:00 PM | Panama | Puerto Rico |
| February 7 | 8:00 PM | Puerto Rico | Dominican Republic |
| February 8 | 3:00 PM | Panama | Dominican Republic |
| February 9 | 7:00 PM | Puerto Rico | Panama |
Final Game:
| Date | Time (ET) | ||
| February 10 | 4:00 PM | Group A Winner | Group B Winner |